Kepp Research

news members research publications contact


July 4, 2017. Kasper speaks at the EICC4 conference
Speaking on the role of metal ions in Alzheimer's disease
May 8, 2017. Kasper will speak at the Danish Annual meeting for Neuroscience
Speaking on the ´molecular causes of ALzheimer's from patient-protein correlations
March 2017. Review of heme's amazing chemical properties and role in life is out.
Heme is the central oxygen manager of life on our planet; without it, it would be hard to imagine oxygen-based life as we know it. Why is heme so special? The review summarizes why.
Feb 2017. Benchmarking DFT for gold: First detailed benchmark of DFT's ability to describe diverse chemical bonds to gold
DFT studies of gold chemistry are common and diverse - but how accurate are they? This paper reports a detailed comparison of commonly used density functionals applied to gold chemistry
Jul 2016. Kasper speaks at the International Conference on Porphyrins and Phthalocyanins. Kasper will speak on the evolution of heme from quantum mechanics of spin crossover to oxygen storage in diving whales
Apr 2016. Protein stability effects are universal: An application towards myoglobin of diving whales.
We report the discovery of generic stability relaxation and a new model that can account for multi-site protein variants.
Feb 2016. The general mess of Aβ (new work published in Alzheimer & Dementia).
Widely used biochemical data of β-amyloid used to support the amyloid hypothesis are heterogeneous and show no relationship to clinical outcome, as shown in our meta analysis. Toxicity and aggregation propensity do not correlate with clinical data and probably do not reflect the human disease.
Sep 2015. The quest for the structure of β-amyloid (new work published in ChemPhysChem)
Commonly used force fields produce major differences in structures of the disordered β-amyloid. We identify the ensembles that best explain experimental NMR and CD data, providing a model of the true β-amyloid ensemble relevant for treating Alzheimer’s disease.
July 2015. Attending the ICCB conference in Kauai, Hawaii, July 2 to 6.  At this meeting, Kasper talks about our results on the mechanisms that control the Fe-O bond in biological processes.

June 2015. Attending the EMBO neurodegeneration meeting in Heidelberg June 14-17.  At the EMBO symposium in Heidelberg, we present our Proteostatic exhaustion mechanism of ALS, that increased proteome maintenance energy is the  cause of ALS, from analysis of ALS-causing SOD1 mutations.

March 2015. Molecular Causes of ALS: Coupling protein energy to real patient data for carriers of SOD1 variants suggest that proteome energy  contributes to disease.  In the most systematic analysis of SOD1 variants so far, we find that patient survival correlates strongly with stability, charge, and in particular misfolded protein copies, suggesting a new theory of neurodegeneration caused by proteome exhaustion.

Feb 2015. New mechanism of laccase inhibition: Halides impair critical reorganization energies.  Laccases,industrially important copper enzymes, are inhibited by small anions, thought to bind to copper and block reactivity. We identified a new mechanism of this inhibition due to changes in the redox properties, distinct from e.g. channel blocking or conformation change. It explains the experimental stronger inhibition of fluoride vs. chloride.

Nov 2014. New patent WO2014167112 for synthesizing sugars  Together with researchers at DTU Chemical Engineering, we have invented a new mutant trans sialidase with enhanced ability to transfer and build  sugars relevant to functional food ingredients.

Nov 2014. First relation between real patient data and biochemical properties of genetic variants causing Alzheimer's disease  We have shown how clinical patient data of carriers of genetic variants (age of disease onset) can be correlated directly with chemical properties of the amyloid mutants that the patients carry. Disordered hydrophobic exposure correlate with disease characteristics, the first identified such correlation in Alzheimer's Disease.

Oct 2014. Søren Brander successfully defends his Ph.D. thesis. Congratulations! Søren's work has resulted in the discovery of several bacterial "laccases"by genome mining of extremophilic organisms. One of the laccases shows improved alkaline and salt tolerance (from B. clausii), and another has the second-highest thermostability ever measured for a laccase. Both serve as important new frameworks for laccase optimization far away in sequence space from known industrial laccases.

Sep 2014. Arun joins our group as a ph.d. student to work on proteins involved in Alzheimer's disease. We are making amyloid mutants in the lab and pinpoint their disease mechanism by molecular simulations.

Dec 2013. Kasper joins the Management commitee of the EU-sponsored COST action on spin states in biochemistry and technology Spin states serve a major and central role in life, including the use of all molecular oxygen from the air, which, as we have shown together with Prof. Ulf Ryde, depnds critically on maintaing energy levels close together during these processes. Still, we do not understand this inherently quantum-mechnical phenomenon very well -- The COST action will help!

Jun 2013. Pouria Dasmeh successfully defends his Ph.D. thesis. Congratulations! How does a protein evolve? Why do the proteins that constitute all living matter around us have exactly those shapes and amino acids that they have? How much is random, how much is specifically required , and how was the selection done? Pouria's work on the evolution of myoglobin, bridging from the basic chemistry to the full organism in diving mammals, is the first of its kind.

Jan 2013. New review on theoretical inorganic chemistry: "Consistent descriptions of metal–ligand bonds and spin-crossover in inorganic chemistry" This review describes the "gos" and "no-gos" in the field of modelling inorganic chemistry, including the difficult challenge of spin states.

Dec 2012. Our research is described in the Danish newspaper Politiken. "New Danish theory can help curing Alzheimer's Disease"
(Ny dansk teori kan styrke kampen mod Alzheimers)

Major Danish newspaper Politiken Dec 9, 2012

Oct 2012. New review in Chemical Reviews on "Bioinorganic Chemistry of Alzheimer's Disease" This review summarizes the current state of biochemistry, including the centra lrole played by iron, zinc, and copper, in Alzheimer's Disease, and collects major combined evidence to argue that zinc underlies the entire amyloid balance previously considered the underlying cause of Alzheimer.

Sep 2012. Kasper speaks as invited speaker at the CECAM workshop in Zaragoza, Sep 18-21.

Copyright 2014. Kasper P. Kepp.