2018: Welcome to Budheswar Dehury, ph.D.
||Budheswar who will work as a postdoc on predicting Alzheimer's disease-causing mutations|
|May 2018: We
have been funded by DFF - thanks!
||Humble thanks to DFF and the Danish taxpayers for supporting our project on developing new protein stability prediction tools|
|May 2018: Kasper silently celebrates his 100th review report for ACS in the Paragon Plus System.||Paragon Plus goes back to 2007, so
that is 10 review reports for ACS per year (and
10-15 for other publishers), 95 of these were delivered
within a few days, typically 1-2 pages per report.
|April-May 2018: Kasper is on family leave from work.||Does not respond to emails except
issues of life-saving importance.
1, 2018. Ning Tang joins our lab as postdoctoral
researcher - Welcome!
||Ning Tang will work on understanding and developing new medicine targeting the large membrane protein complex gamma secretase involved in Alzheimer's Disease (funded by DFF).|
|Jan 1, 2018. Rukmankesh will join our group as postdoctoral researcher - Welcome!||Rukmankesh will study laccases in
collaboration with Prof. Anne Meyer, DTU Chemical
Engineering - the project is funded by DFF.
|Dec 12, 2017. Arun will defend his ph.d. thesis on proteins in Alzheimer's Disease.||Arun has studied proteins in
Alzheimer's Disease both experimentally and
computationally and published six papers in three
years, taken half a year of courses and been at two
|Dec 7, 2017. NNF awards us funding for a two-years postdoc. Thanks!||The project will explore the causes and disease properties of mutations in Alzheimer's disease.|
4, 2017. Kasper speaks at the EICC4 conference
||Speaking on the role of metal
ions in Alzheimer's disease
8, 2017. Kasper will speak at the Danish
Annual meeting for Neuroscience
||Speaking on the ´molecular
causes of ALzheimer's from patient-protein
of heme's amazing chemical properties and role in life
||Heme is the central oxygen
manager of life on our planet; without it, it
would be hard to imagine oxygen-based life as we
know it. Why is heme so special? The
review summarizes why.
DFT for gold: First detailed benchmark of DFT's
ability to describe diverse chemical bonds to gold
||DFT studies of gold chemistry
are common and diverse - but how accurate are
paper reports a detailed comparison of
commonly used density functionals applied to gold
|Jul 2016. Kasper speaks at the International Conference on Porphyrins and Phthalocyanins.||Kasper will speak on the
evolution of heme from quantum mechanics of spin
crossover to oxygen storage in diving whales
stability effects are universal: An
application towards myoglobin of diving whales.
||We report the discovery of generic stability relaxation and a new model that can account for multi-site protein variants.|
general mess of Aβ (new
work published in Alzheimer & Dementia).
||Widely used biochemical data of β-amyloid used to support the amyloid hypothesis are heterogeneous and show no relationship to clinical outcome, as shown in our meta analysis. Toxicity and aggregation propensity do not correlate with clinical data and probably do not reflect the human disease.|
quest for the structure of β-amyloid (new
work published in ChemPhysChem)
||Commonly used force fields produce major differences in structures of the disordered β-amyloid. We identify the ensembles that best explain experimental NMR and CD data, providing a model of the true β-amyloid ensemble relevant for treating Alzheimer’s disease.|
|July 2015. Attending the ICCB conference in Kauai, Hawaii, July 2 to 6.||At this meeting,
Kasper talks about our results on the mechanisms
that control the Fe-O bond in biological processes.
|June 2015. Attending the EMBO neurodegeneration meeting in Heidelberg June 14-17.||At the EMBO
symposium in Heidelberg, we present our
Proteostatic exhaustion mechanism of ALS, that
increased proteome maintenance energy is the
cause of ALS, from analysis of ALS-causing SOD1
|March 2015. Molecular Causes of ALS: Coupling protein energy to real patient data for carriers of SOD1 variants suggest that proteome energy contributes to disease.||In the most
systematic analysis of SOD1 variants so far,
we find that patient survival correlates strongly
with stability, charge, and in particular misfolded
protein copies, suggesting a new theory of
neurodegeneration caused by proteome exhaustion.
|Feb 2015. New mechanism of laccase inhibition: Halides impair critical reorganization energies.||Laccases,industrially
important copper enzymes, are inhibited by small
anions, thought to bind to copper and block
identified a new mechanism of this inhibition
due to changes in the redox properties, distinct
from e.g. channel blocking or conformation change.
It explains the experimental stronger inhibition of
fluoride vs. chloride.
|Nov 2014. New patent WO2014167112 for synthesizing sugars||Together with
researchers at DTU Chemical Engineering, we have invented a new
mutant trans sialidase with enhanced ability
to transfer and build sugars relevant to
functional food ingredients.
|Nov 2014. First relation between real patient data and biochemical properties of genetic variants causing Alzheimer's disease||We have shown
how clinical patient data of carriers of genetic
variants (age of disease onset) can be correlated
directly with chemical properties of the amyloid
mutants that the patients carry. Disordered
hydrophobic exposure correlate with disease
characteristics, the first identified such
correlation in Alzheimer's Disease.
|Oct 2014. Søren Brander successfully defends his Ph.D. thesis. Congratulations!||Søren's work
has resulted in the discovery of several bacterial
"laccases"by genome mining of extremophilic
organisms. One of the laccases shows improved
alkaline and salt tolerance (from B. clausii),
and another has the second-highest
thermostability ever measured for a laccase.
Both serve as important new frameworks for laccase
optimization far away in sequence space from known
|Sep 2014. Arun joins our group as a ph.d. student to work on proteins involved in Alzheimer's disease.||We are making
amyloid mutants in the lab and pinpoint their
disease mechanism by molecular simulations.
|Dec 2013. Kasper joins the Management commitee of the EU-sponsored COST action on spin states in biochemistry and technology||Spin states serve a major and
central role in life, including the use of all molecular
oxygen from the air, which, as we have shown
together with Prof. Ulf Ryde, depnds critically on
maintaing energy levels close together during these
processes. Still, we do not understand this
inherently quantum-mechnical phenomenon very well --
The COST action will help!
|Jun 2013. Pouria Dasmeh successfully defends his Ph.D. thesis. Congratulations!||How does a
protein evolve? Why do the proteins that constitute
all living matter around us have exactly those
shapes and amino acids that they have? How much is
random, how much is specifically required , and how
was the selection done? Pouria's work on the
evolution of myoglobin, bridging from the basic
chemistry to the full organism in diving mammals,
is the first of its kind.
|Jan 2013. New review on theoretical inorganic chemistry: "Consistent descriptions of metal–ligand bonds and spin-crossover in inorganic chemistry"||This
review describes the "gos" and "no-gos" in the
field of modelling inorganic chemistry, including
the difficult challenge of spin states.
|Dec 2012. Our research is described in the Danish newspaper Politiken.||"New Danish
theory can help curing Alzheimer's Disease"
(Ny dansk teori kan styrke kampen mod Alzheimers)
Major Danish newspaper Politiken Dec 9, 2012
|Oct 2012. New review in Chemical Reviews on "Bioinorganic Chemistry of Alzheimer's Disease"||This
review summarizes the current state of
biochemistry, including the centra lrole played by
iron, zinc, and copper, in Alzheimer's Disease, and
collects major combined evidence to argue that zinc
underlies the entire amyloid balance previously
considered the underlying cause of Alzheimer.
|Sep 2012. Kasper speaks as invited speaker at the CECAM workshop in Zaragoza, Sep 18-21.|
|Copyright 2014. Kasper P. Kepp.|